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Trospium Chloride, Oral TROS-pee-um KLOR-ide

What are other names for this medicine?

Type of medicine: antispasmodic; anticholinergic

Generic and brand names: trospium chloride, oral; Sanctura; Sanctura XR

What is this medicine used for?

This medicine is taken by mouth to treat the symptoms of urinary frequency, urinary urgency, urinary leakage, and incontinence caused by bladder spasms.

What should my healthcare provider know before I take this medicine?

Before taking this medicine, tell your healthcare provider if you have ever had:

  • an allergic reaction to any medicine
  • a blockage in your stomach, intestines, or urinary tract
  • an enlarged prostate or inability to urinate
  • chronic constipation
  • glaucoma
  • kidney or liver disease
  • muscle diseases such as myasthenia gravis
  • severe ulcerative colitis

Females of childbearing age: Tell your healthcare provider if you are pregnant or plan to become pregnant. It is not known whether this medicine will harm an unborn baby. Do not breast-feed while taking this medicine without your healthcare provider's approval.

How do I take it?

Check the label on the medicine for directions about your specific dose. Take this medicine exactly as prescribed. Do not take more than directed because increasing the dosage increases the risk of side effects.

This medicine may come in different forms. If you have the extended-release capsule, do not open, crush, or chew the capsule. Swallow the capsule whole. Ask your pharmacist if you have the extended-release capsules.

It is best to take this medicine on an empty stomach 1 hour before meals. Do not take this medicine with a meal high in fat and calories. Fat makes the medicine less effective. Do not drink alcohol within 2 hours of taking this medicine.

What if I miss a dose?

If you miss a dose, take it 1 hour before your next meal. Do not take double doses. If you are not sure of what to do if you miss a dose, or if you miss more than one dose, contact your healthcare provider.

What if I overdose?

If you or anyone else has intentionally taken too much of this medicine, call 911 or go to the emergency room right away. If you pass out, have seizures, weakness or confusion, or have trouble breathing, call 911. If you think that you or anyone else may have taken too much of this medicine, call the poison control center. Do this even if there are no signs of discomfort or poisoning. The poison control center number is 800-222-1222.

Symptoms of an acute overdose may include: dry mouth, drowsiness, blurred vision, large pupils, hot dry skin, severe constipation, stomach pain, decreased urination, irregular heartbeat.

What should I watch out for?

Dry mouth is a common side effect of this medicine. If it becomes bothersome, tell your healthcare provider.

This medicine may cause blurred vision, dizziness, or drowsiness. Do not drive or operate machinery unless you are fully alert and able to see clearly.

This medicine increases the risk of heat stroke because it reduces sweating. Avoid extreme heat, saunas, hot tubs, and exercising too much.

This medicine increases the effects of alcohol and other medicines that slow down the nervous system. Do not drink alcohol or take other medicines that make you drowsy unless your healthcare provider approves.

This medicine may make you constipated. You may need to take a laxative or stool softener while taking this medicine. Talk with healthcare provider or pharmacist about this.

Adults over the age of 75 may be at greater risk for side effects such as nervousness or drowsiness. Talk with your healthcare provider about this.

If you need emergency care, surgery, or dental work, tell the healthcare provider or dentist you are taking this medicine.

What are the possible side effects?

Along with its needed effects, your medicine may cause some unwanted side effects. Some side effects may be very serious. Some side effects may go away as your body adjusts to the medicine. Tell your healthcare provider if you have any side effects that continue or get worse.

Life-threatening (Report these to your healthcare provider right away. If you cannot reach your healthcare provider right away, get emergency medical care or call 911 for help): Allergic reaction (hives; itching; rash; trouble breathing; tightness in your chest; swelling of your lips, tongue, and throat) or seizures.

Serious (report these to your healthcare provider right away): Chest pain, fast heartbeat, hallucinations, fainting, confusion, inability to urinate, very high or low blood pressure.

Other: Constipation, dry eyes, dry mouth, decreased sweating, nausea, headache, vomiting, change in sense of taste, dizziness, blurred vision, stomach ache, drowsiness.

What products might interact with this medicine?

When you take this medicine with other medicines, it can change the way this or any of the other medicines work. Nonprescription medicines, vitamins, natural remedies, and certain foods may also interact. Using these products together might cause harmful side effects. Talk to your healthcare provider if you are taking:

  • anticholinergic medicines such as atropine sulfate, benztropine (Cogentin), dicyclomine (Bentyl), hyoscyamine (Levsin), methscopolamine (Pamine), propantheline, and trihexyphenidyl
  • antihistamines in many cold and allergy medicines such as antihistamines such as chlorpheniramine (Chlor-Trimeton), diphenhydramine (Benadryl), hydroxyzine (Vistaril), and meclizine (Antivert, Dramamine)
  • heart medicines such as procainamide (Procan-SR) and dofetilide (Tikosyn)
  • metformin (Glucophage, Riomet, Glucovance)
  • narcotic pain medicines such as codeine, fentanyl (Duragesic, Actiq), hydrocodone/acetaminophen (Vicodin, Lortab), hydromorphone (Dilaudid), meperidine (Demerol), methadone (Dolophine), morphine (Kadian, MS Contin), oxycodone (OxyContin, Roxicodone), oxycodone/acetaminophen (Percocet, Tylox), and pentazocine (Talwin)
  • tenofovir (Viread)
  • tricyclic antidepressants such as amitriptyline, desipramine (Norpramin), doxepin, imipramine (Tofranil), and nortriptyline (Pamelor)
  • vancomycin (Vancocin)

If you are not sure if your medicines might interact, ask your pharmacist or healthcare provider. Keep a list of all your medicines with you. List all the prescription medicines, nonprescription medicines, supplements, natural remedies, and vitamins that you take. Be sure that you tell all healthcare providers who treat you about all the products you are taking.

How should I store this medicine?

Store this medicine at room temperature. Keep the container tightly closed. Protect it from heat, high humidity, and bright light.


This advisory includes selected information only and may not include all side effects of this medicine or interactions with other medicines. Ask your healthcare provider or pharmacist for more information or if you have any questions.

Ask your pharmacist for the best way to dispose of outdated medicine or medicine you have not used. Do not throw medicine in the trash.

Keep all medicines out of the reach of children.

Do not share medicines with other people.


Developed by RelayHealth.
Medication Advisor 2012.1 published by RelayHealth.
Last modified: 2011-10-31
Last reviewed: 2010-12-20
This content is reviewed periodically and is subject to change as new health information becomes available. The information is intended to inform and educate and is not a replacement for medical evaluation, advice, diagnosis or treatment by a healthcare professional.
© 2012 RelayHealth and/or its affiliates. All rights reserved.
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